I just noticed this recently, I cannot save my blend file. Cannot open file for writing permission denied.
I have been using Blender for over 5 years and installed it multiple times on multiple computers. I cannot save on C: drive all of a sudden and I have went into properties on the drive and allowed all permissions.
I can only use blender now as an administrator which is annoying and ridiculous. I am using windows 10 which it never used to do this before.
All of a sudden, an update or security setting may have done this but I have tried everything--forums, youtube, etc. and nothing fixes this problem.
I know I am not the only one to be having this problem via forums.
This may not be a Blender issue directly but I think your team should look into why this is occurring on multiple computers, I have 3, all around the same time frame-within a week.
This is a Blender windows 10 issue. I have uninstalled the program, files, and downloaded the installer - like I have multiple times in multiple years - and installed it the same way from the website and it does not fix the problem.
Only Blender is affected - no other programs that I have, photoshop, gimp, paint, etc. ... Please look into this and thank you.