A way of automate it could be to use an Application Handler, I think one of the scene update handlers would be the best fit. As you only want to alter the value once I would have the handler remove itself once it has done it's task.
As batFinger pointed out, it would also be useful to setup a persistent handler that will set the value when another file is loaded.
bl_info = {"name": "Set property", "version": (1, 0), "location": "blender",
"description": "Test a way of setting a default property.",
"warning": "Only testing", "category": "Test",
}
import bpy
from bpy.app.handlers import persistent
@persistent
def setIt(scene):
scene.world.use_sky_paper = True
bpy.app.handlers.scene_update_pre.remove(setIt)
def register():
bpy.app.handlers.scene_update_pre.append(setIt)
bpy.app.handlers.load_post.append(setIt)
def unregister():
bpy.app.handlers.load_post.remove(setIt)
if __name__ == "__main__":
register()
world.use_sky_paper = True
?? $\endgroup$