I am trying to create a model of wrist bones from a CT scan. The individual bones all have quite a number of holes and an interior structure (bone marrow) that is not relevant, but very hard to remove. I am now trying to create a smooth surface model from it. Running the smooting modifier will create an acceptable image for most parts, but the many holes are really ugly. I would like to simply the surface (reduce the number of vertices, currently about 33,000) and close the holes. I tried fixing the holes manually by adding faces, but this doesn't really work well. Since the surface is in continuity with the inside of the bone, finding the boundaries of the holes also does not really work.
Thanks so much for any suggestion.