I want the holes in the beads to follow the rope/tube/curve that I have them following, but I can't figure out a way to make them have individual rotations and can't find a tutorial to help me.
I don't want to be the know-it-all here again, but this kind of question always leads to
Align Euler to Vector in many answers.
But it would be much easier to convert the curve directly into points with
Curve to Points, whereby the rotation of each point is directly available and the orientation of the objects to be instantiated always follows the curve exactly.
The advantage of this solution is that the Curve Tilt is also respected and the rotation does not have to be tinkered with several nodes.
If you have this setting, where the pearl (the object that will be instantiated) has its hole along the Y axis (the green line):
We want to orientate this Y axis along the curve tangent. So you can get the
Curve Tangent node as a target vector for
Align Euler to Vector and choose the Y axis to be oriented to this tangent.
In the same principle, you can also use the X axis (in red), which is on the side of the pearl. To be rotated appropriately, this axis has to be along the curve normal. So you can also choose this setting, where the X axis is this time oriented to normal:
Align Euler to Vector has no Rotation input here, as the default rotation is $(0, 0, 0)$.
So the output rotation is just what is needed to go either from tangent or normal to make the pearl follow the curve orientation.