Just for curiosity. I don't find enough information about this, even in documentation. I don't see any difference when I use it.
It controls whether to keep intersecting edges perpendicular to the bevel direction.
Loopslide On: gives smoother topology and better results for tight geometry
Loopslide Off: keeps perpendicular edges and even bevel width
When Clamp Overlap isn't enough, Loopslide On can keep the topology in check: