Sounds like I'm having the same issue as this question (Missing cache error) but since that has no answers, I figured I'd post this question with a working example of my issue.
I have a bunch of tubular structures that I build and mesh using metaballs. The issue is that sometimes there is a small amount of overlap between the meshes so I've written a script which uses soft body collisions to reduce the overlap (this may be overkill but I've found no other satisfactory way to do it).
The problem is that when I have more than a couple of meshes, I get this 'missing cache error' being printed to the console over and over again. It doesn't actually stop the simulation but that much printing to the console slows the whole process down.
Does anyone know the cause of this error message, whether it actually affects the result of the simulation and how to stop it?