This question already has an answer here:
Whenever I download a .blend from someone all of the windows and settings are the way they have left them as it is saved in the file. It takes way to long to rearrange every window and toolbar to the way it is by default. Is there any tool or shortcut that can reset the UI to blenders default and just leave the actual contents of the file? The only way I could do this is by creating a new file and using link/append but this is not the best option.